Compatibility «Deprim» and «Deprim forte»

• Interactions Deprim with Deprim forte

  • Dangerous interactions
    • ⓘ The simultaneous use of St. John's wort with cyclosporine, sirolimus, tacrolimus or indinavir and other protease inhibitors used to treat HIV, irinotecan and other cytostatics, as well as antidepressants is not recommended (see the section Contraindications).
  • Negative interactions
    • ⓘ Drugs: Deprim and Deprim forte there is common active substance : Hyperici perforati herbae extract. Pay attention to the dosage..
    • ⓘ Theoretically, it is possible to enhance the phototoxic effect of St. John's wort when combined with photosensitizing drugs.
    • ⓘ Preparations containing St. John's wort herb extract can reduce the concentration of drugs metabolized with the participation of cytochrome P450 isoenzyme CYP3A4, CYP2C9, CYP2C19 or transported by P-gp.
    • ⓘ Hyperici perforati herbae extract and St. John s wort herb dry extract belong to the same pharmaceutical group: Sedatives.
    • ⓘ Hyperici perforati herbae extract and St. John s wort herb dry extract belong to the same pharmaceutical group: Antidepressants.
  • No interactions
    • ⓘ St. John's wort dry extract may promote serotonergic effects in combination with antidepressants such as serotonin reuptake inhibitors (e.g. sertraline, paroxetine, nefazodone), buspirone or triptans.
  • Positive interactions
    • ⓘ With the simultaneous use of St. John's wort with a number of antidepressants (nefazodone, paroxetine, sertraline), the pharmacological effect of the latter may increase.
  • Unclear interactions
    • ⓘ St. John's wort preparations induce the activity of cytochrome P 450 enzymes.
    • ⓘ In women, with the simultaneous use of St. John's wort with low-dose hormonal contraceptives, intermenstrual bleeding is possible.
    • ⓘ Before using the drug based on St. John's wort extract, patients taking other drugs should consult their doctor.
    • ⓘ Hyperici perforati herbae extract + St. John s wort herb dry extract analgin and citramon are used together in Deprim forte.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,039,738 possible combinations of drugs and their components were found 412,575 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-28

Category - medicine