Compatibility «Lamictal» and «Qlaira»

• Interactions Lamictal with Qlaira

  • Negative interactions
    • ⓘ In 16 female volunteers, oral contraceptives containing 30 mcg of ethinyl estradiol and 150 mcg of levonorgestrel increased the apparent clearance of lamotrigine (300 mg/ day) by about 2 times with an average decrease in AUC by 52% and max'>C_max by 39%.
    • ⓘ For women taking estrogen-containing oral contraceptives, a dose adjustment of lamotrigine may be required.
    • ⓘ COCs can affect the metabolism of other drugs, which leads to an increase (for example, cyclosporine) or a decrease (for example, lamotrigine) in their concentration in blood plasma and tissues.
    • ⓘ It was reported that ethinyl estradiol, rather than progestogens, increased the clearance of lamotrigine by 2 times, and tablets containing only progestins did not affect the concentration of lamotrigine in blood plasma.
  • No interactions
    • ⓘ In the same study, the combined use of lamotrigine (300 mg/ day) in 16 female volunteers did not affect the pharmacokinetics of ethinyl estradiol in a combined oral contraceptive drug.
  • Unclear interactions
    • ⓘ Oral contraceptives (e.g. ethinyl estradiol + levonorgestrel)³.
    • ⓘ ³ The effect of other hormonal contraceptives or HRT on the pharmacokinetics of lamotrigine has not been systematically evaluated in clinical studies, although the effect may be similar to that observed with the combination of ethinyl estradiol + levonorgestrel.
    • ⓘ Estrogen-containing oral contraceptives.
    • ⓘ Other hormonal contraceptives or HRT.
    • ⓘ The effect of other hormonal contraceptives or HRT on the pharmacokinetics of lamotrigine has not been systematically evaluated.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,037,924 possible combinations of drugs and their components were found 412,574 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-05-07

Category - medicine