Genetic markers of increased risk of adverse reactions when taking methotrexate

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Genetic markers of increased risk of adverse reactions when taking methotrexate (Selected) —
A genetic marker of the risk of adverse reactions when taking NSAIDs—
A marker of resistance to antiplatelet therapy with aspirin and plavix—
ACE inhibitors, fluvastatin, ATII receptor blockers—
Beta-blockers. The CYP2D6 gene. Pharmacogenetics—
Genetic factors of Penicillamine Effectiveness—
Genetic marker of the risk of metabolic disorders of Losartan and irbesartan—
Genetic markers of risk when taking hydralazine and procainamide—
Genetic markers of the risk of polyneuritis when taking isoniazid—
Investigation of the probability of side effects of sulfonamides—
Metabolism of irinotecan, UGT1A1—
Study of the clinical efficacy of statins—
Sulfonylurea and its derivatives: chlorpropamide, tolazamide, glibenclamide and tolbutamide—

Preparation

Специальной подготовки к исследованию не требуется.

Description

Метод определения ПЦР и рестрикционный анализ. Выдаётся описание результатов врачом-генетиком.
Исследуемый материал Цельная кровь (с ЭДТА).
Генетические маркёры повышенного риска развития побочных реакций при приёме метотрексата на фоне лечения ревматоидного артрита. Метотрексат нарушает метаболизм фолиевой кислоты. Определение наличия полиморфизмов в генах ферментов реакций фолатного цикла. MTHFR (7211 и 7571), MTRR (7591), MTR (7581).
Источник: Invitro.

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