Compatibility «Erythromycin ointment 10000 IU/g» and «Эторикоксиб ЛЕКАС»
Between «Erythromycin ointment 10000 IU/g» and «Эторикоксиб ЛЕКАС» found 1 dangerous and 1 negative interaction, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Эторикоксиб ЛЕКАС |
| ✘Erythromycin ointment 10000 IU/g [Erythromycin] Analogs | |
| ✘Эторикоксиб ЛЕКАС [Etoricoxib] Analogs |
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Interactions Erythromycin ointment 10000 IU/g with Эторикоксиб ЛЕКАС
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Dangerous interactions
- Concomitant oral administration of voriconazole or the use of topical miconazole gel, strong CYP3A4 inhibitors, and etoricoxib caused a slight increase in the pharmacological activity of etoricoxib, but this effect is not considered clinically significant.
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Negative interactions
- Based on in vitro studies, it is expected that etoricoxib does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 or CYP3A4.
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No interactions
- Ketoconazole, a strong CYP3A4 inhibitor, taken at a dose of 400 mg once daily for 11 days by healthy volunteers, did not have a clinically significant effect on the pharmacokinetics of a single dose of 60 mg of etoricoxib (an increase in AUC by 43%).
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Unclear interactions
- In a study involving healthy volunteers, daily intake of etoricoxib at a dose of 120 mg did not change the activity of hepatic CYP3A4 according to the results of a respiratory test with erythromycin.
- CYP3A4 appears to be involved in the metabolism of etoricoxib in vivo.
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Dangerous interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,999,821 possible combinations of drugs and their components were found 412,536 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2025-02-20
Category - medicine