Compatibility «Zinc acetate+Erythromycin» and «Vero-Amiodarone»

• Interactions Zinc acetate+Erythromycin with Vero-Amiodarone

  • Dangerous interactions
    • ⓘ When combining amiodarone, an inhibitor of the CYP3A4 isoenzyme, with these drugs, which are substrates of the CYP3A4 isoenzyme, it is possible to increase their plasma concentrations, which may lead to an increase in their toxicity and / or increased pharmacodynamic effects, and may also require a reduction in their doses.
    • ⓘ Increased risk of muscle toxicity (rhabdomyolysis) with simultaneous use of amiodarone and statins metabolized by the CYP3A4 isoenzyme.
    • ⓘ Inhibitors of the CYP3A4 and CYP2C8 isoenzymes may have the potential to inhibit amiodarone metabolism, increase its concentration in the blood and, accordingly, the risk of increasing its pharmacodynamic and side effects.
    • ⓘ It is recommended to avoid taking inhibitors of the CYP3A4 isoenzyme (for example, grapefruit juice and certain drugs such as cimetidine and HIV protease inhibitors, in pm indinavir) during treatment with amiodarone.
  • Negative interactions
    • ⓘ Drugs that are inducers of CYP3A4 isoenzymes (such as rifampicin, phenytoin, carbamazepine, phenobarbital, St. John's wort) can induce erythromycin metabolism, which can lead to subtherapeutic concentrations of erythromycin and a decrease in its effect.
    • ⓘ Amiodarone and/or its metabolite desethylamiodarone inhibit the isoenzymes CYP1A1, CYP1A2, CYP3A4, CYP2C9, CYP2D6 and P-gp and may increase the systemic exposure of drugs that are their substrates.
    • ⓘ It is recommended to use statins that are not metabolized by the CYP3A4 isoenzyme.
    • ⓘ Amiodarone inhibits the isoenzymes CYP2D6 and CYP3A4 and theoretically can increase the plasma concentration of dextromethorphan.
    • ⓘ Inhibitors of CYP3A4 and CYP2C8 isoenzymes.
    • ⓘ Rifampicin is a powerful inducer of the CYP3A4 isoenzyme, when used in combination with amiodarone, it can reduce plasma concentrations of amiodarone and desethylamiodarone.
    • ⓘ St. John's wort is a powerful inducer of the CYP3A4 isoenzyme.
  • No interactions
    • ⓘ The interaction persists for 2 weeks after discontinuation of treatment with CYP3A4 inducers.
  • Positive interactions
    • ⓘ Macrolides (J01FA) + Benzodiazepines (midazolam, triazolam), cardiac glycosides (digoxin), antiarrhythmic agents (disopyramide) => Enhancement of the effect of these drugs.
  • Unclear interactions
    • ⓘ (levofloxacin, moxifloxacin, sparfloxacin, ciprofloxacin); macrolides (erythromycin with intravenous administration, azithromycin, clarithromycin, roxithromycin, spiramycin), co‑trimoxazole;.
    • ⓘ Medicinal products that are substrates of the CYP3A4 isoenzyme.
    • ⓘ Other drugs metabolized by the CYP3A4 isoenzyme:.
    • ⓘ A drug that is a substrate of the isoenzymes CYP2D6 and CYP3A4.
    • ⓘ Inducers of the CYP3A4 isoenzyme.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine