Compatibility «Hydrochlorothiazide» and «Dexamethasone»
Between «Hydrochlorothiazide» and «Dexamethasone» found 2 dangerous and 6 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Dexamethasone |
✘Hydrochlorothiazide Analogs | |
✘Dexamethasone Analogs |
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Interactions Hydrochlorothiazide with Dexamethasone
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Dangerous interactions
It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. Reduce the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), enhance - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin In and carbonic anhydrase inhibitors, the risk of erosive ulcerative lesions and bleeding from the gastrointestinal tract - NSAIDs. -
Negative interactions
Diuretics, Diacarb, dichlotiazide, furosemide, ethacric acid + Amphotericin B, glucocorticoids, corticotropin, cardiac glycosides, laxatives and other agents that promote the excretion of potassium from the body => Cardiac dysfunction, muscle weakness and other manifestations of hypokalemia. It weakens the hypoglycemic activity of insulin and oral antidiabetic agents, anticoagulant - coumarins, diuretic - diuretics, immunotropic - vaccinations (suppresses antibody formation). With the simultaneous use of non-potassium-sparing diuretics, in pm thiazide, with other drugs that increase the risk of hypokalemia, such as GCS, additive hypokalemia may occur. GCS may increase the loss of electrolytes associated with diuretic therapy, which leads to hypokalemia. GCS may increase the loss of electrolytes associated with diuretic therapy, leading to hypokalemia and/or hypomagnesemia. Glucocorticoids (H02AB), mineralocorticoids (H02AA) + Diuretics that enhance the excretion of potassium ions (dichlothiazide, etc.), cardiac glycosides, amphotericin B => Hypokalemia syndrome; cardiac arrhythmia, muscle weakness, etc. -
Unclear interactions
Thiazide diuretics.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine