Compatibility «Diltiazem» and «Betmiga»
Between «Diltiazem» and «Betmiga» found 2 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
-
Interactions Diltiazem with Betmiga
-
Negative interactions
Hypoglycemic drugs, sulfonylurea derivatives such as glibenclamide (CYP3A4 substrate), gliclazide (CYP2C9 and CYP3A4 substrate) and tolbutamide (CYP2C9 substrate) do not affect mirabegron metabolism in vitro. Studies have shown that ketoconazole, a strong CYP3A4 inhibitor, increased the systemic effect of mirabegron: max'>Cmax mirabegron increased by 45% and AUC by 80% after repeated administration of ketoconazole at a dose of 400 mg for 9 days before using a single dose mirabegron 100 mg in 23 healthy male and female subjects. -
Unclear interactions
Mirabegron is a substrate of CYP3A4, CYP2D6, butyrylcholinesterase, UDP-GT, P-gp and organic cation transporters (OST) OCT1, OCT2 and OST 3.
-
Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine