Compatibility «Esomeprazol» and «Dexamethasone»
Between «Esomeprazol» and «Dexamethasone» found 4 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Dexamethasone |
| ✘Esomeprazol Analogs | |
| ✘Dexamethasone Analogs |
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Interactions Esomeprazol with Dexamethasone
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Negative interactions
- The combined oral administration of esomeprazole and clarithromycin, an inhibitor of the CYP3A4 isoenzyme (500 mg 2 times a day), leads to a twofold increase in the AUC of esomeprazole.
- Concomitant use of esomeprazole and a combined inhibitor of CYP3A4 and CYP2C19 isoenzymes, for example voriconazole, can lead to an increase in the AUC of esomeprazole up to 280%.
- Drugs that induce CYP2C19 and CYP3A4 isoenzymes, such as rifampicin and St. John's wort preparations, when used concomitantly with esomeprazole, can lead to a decrease in the concentration of esomeprazole in blood plasma by accelerating its metabolism.
- If simultaneous use of dexamethasone (a moderate CYP3A4 inducer) is necessary, it is necessary to monitor the decrease in the effectiveness of esomeprazole (CY2C19 and CYP3A4 substrate).
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Unclear interactions
- The isoenzymes CYP2C19 and CYP3A4 are involved in the metabolism of esomeprazole.
- Esomeprazole.
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Negative interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2025-11-20
Category - medicine