Compatibility «Spironolactone» and «Hydrochlorothiazide»
Between «Spironolactone» and «Hydrochlorothiazide» found 5 dangerous and 7 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Hydrochlorothiazide |
✘Spironolactone Analogs | |
✘Hydrochlorothiazide Analogs |
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Interactions Spironolactone with Hydrochlorothiazide
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Dangerous interactions
Lithium-containing drugs, as a rule, should not be prescribed with diuretics. Diuretics reduce the renal clearance of lithium, increasing its concentration in blood plasma and the risk of its toxicity. Diuretics reduce the renal clearance of lithium and increase the risk of developing toxic effects of lithium preparations. It should be used with caution with hypotensive drugs (their effect is potentiated, dose adjustment may be necessary), cardiac glycosides (hypokalemia and hypomagnesemia associated with the action of thiazide diuretics may increase the toxicity of digitalis), amiodarone (its use simultaneously with thiazide diuretics may lead to an increased risk of arrhythmias associated with hypokalemia), hypoglycemic oral medications (their effectiveness decreases, hyperglycemia may develop), corticosteroids, calcitonin (increase potassium excretion), NSAIDs (may weaken the diuretic and hypotensive effects of thiazides), non-depolarizing muscle relaxants (their effect may be enhanced), amantadine (clearance of amantadine may decrease with hydrochlorothiazide, which leads to an increase in plasma concentration of amantadine and possible toxicity), colestyramine (reduces absorption of hydrochlorothiazide), ethanol, barbiturates and narcotic analgesics, which enhance the effect of orthostatic hypotension. Hypokalemia and hypomagnesemia caused by the action of thiazide diuretics increase the toxicity of cardiac glycosides. -
Negative interactions
In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, with the simultaneous use of spironolactone and NSAIDs, it is necessary to closely monitor the patient to determine whether the desired effect of the diuretic is achieved. Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Thus, while taking spironolactone with NSAIDs, the patient's condition should be carefully monitored to achieve the desired effect of the diuretic drug. Lithium preparations: as a rule, lithium preparations should not be used in conjunction with diuretics. Carbamazepine: when used concomitantly with diuretics, the drug may cause clinically significant hyponatremia. -
Positive interactions
Simultaneous use of other diuretics: increased diuresis.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine