Compatibility «Spironolactone» and «Indapamide»
Between «Spironolactone» and «Indapamide» found 6 dangerous and 12 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Indapamide |
✘Spironolactone Analogs | |
✘Indapamide Analogs |
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Interactions Spironolactone with Indapamide
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Dangerous interactions
Lithium-containing drugs, as a rule, should not be prescribed with diuretics. Diuretics reduce the renal clearance of lithium, increasing its concentration in blood plasma and the risk of its toxicity. Diuretics reduce the renal clearance of lithium and increase the risk of developing toxic effects of lithium preparations. In chronic heart failure, treatment with ACE inhibitors should begin with the lowest doses, with a possible preliminary reduction in doses of diuretics. Functional renal insufficiency, which can occur against the background of taking diuretics, especially 'loop' ones, while prescribing metformin increases the risk of lactic acidosis. Dehydration of the body while taking diuretic drugs increases the risk of acute renal failure, especially when using high doses of iodine-containing contrast agents. -
Negative interactions
In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, with the simultaneous use of spironolactone and NSAIDs, it is necessary to closely monitor the patient to determine whether the desired effect of the diuretic is achieved. Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Thus, while taking spironolactone with NSAIDs, the patient's condition should be carefully monitored to achieve the desired effect of the diuretic drug. Lithium preparations: as a rule, lithium preparations should not be used in conjunction with diuretics. Carbamazepine: when used concomitantly with diuretics, the drug may cause clinically significant hyponatremia. If necessary, diuretic drugs can be used in combination with lithium preparations, while carefully selecting the dose of drugs, regularly monitoring the concentration of lithium in blood plasma and selecting the dose of the drug accordingly. Patients with arterial hypertension and possibly reduced sodium content in blood plasma due to taking diuretics should:. 3 days before the start of treatment with an ACE inhibitor, stop taking diuretics; in the future, if necessary, taking a non-potassium-sparing diuretic can be resumed;. if discontinuation of diuretics is not possible, then ACE inhibitor therapy should be started at low doses, followed by a gradual increase in the dose if necessary. If simultaneous use of indapamide with potassium-sparing diuretics is necessary, then the potassium content in blood plasma, ECG readings should be monitored and, if necessary, therapy should be adjusted. -
No interactions
The simultaneous use of indapamide with potassium-sparing diuretics is advisable in some patients. -
Positive interactions
Simultaneous use of other diuretics: increased diuresis. -
Unclear interactions
Potassium-sparing diuretics (amiloride, spironolactone, triamterene).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine