Compatibility «Spironolactone» and «Captopril»
Between «Spironolactone» and «Captopril» found 6 dangerous and 10 negative interactions, joint admission is not recommended without consulting a doctor.
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Interactions Spironolactone with Captopril
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Dangerous interactions
Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia. Since ACE inhibitors reduce the production of aldosterone, drugs of this group should not be used in conjunction with spironolactone on a regular basis, especially in patients with established renal dysfunction. In the elderly, patients with hypovolemia (in pm receiving diuretics) or impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including captopril, may lead to deterioration of renal function, including the possible development of acute renal failure. With simultaneous use of a diuretic, the risk of developing side effects of lithium may increase. With the simultaneous use of ACE inhibitors (especially in combination with diuretics) and lithium preparations, an increase in the lithium content in the blood serum is possible, and therefore an increase in the cardiotoxic and neurotoxic effects of lithium preparations. In patients with risk factors (elderly age, hypovolemia, concomitant use of diuretics, impaired renal function), concomitant use of nonsteroidal anti-inflammatory drugs (including cyclooxygenase inhibitors‑2) and ACE inhibitors (including captopril), can lead to deterioration of renal function, up to acute renal failure. -
Negative interactions
Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia. Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary. Patients receiving diuretics, especially with their recent appointment, as well as patients on a diet with strict salt restriction or dialysis, may sometimes experience a sharp decrease in blood pressure, usually within the first hour after taking the initial dose of captopril. The antihypertensive effect can be minimized by discontinuing the diuretic, or by increasing salt intake about a week before the start of captopril or starting therapy with small doses of captopril (6.25 or 12.5 mg). Potassium-sparing diuretics such as spironolactone, triamterene or amiloride, or potassium supplements should be prescribed only with documented hypokalemia and with caution, since their use can lead to a significant increase in serum potassium levels. Simultaneous use of captopril with potassium-sparing diuretics (such as spironolactone, eplerenone, triamterene, amiloride), potassium preparations, potassium-containing salt substitutes and other drugs capable of increasing the potassium content in blood serum (including angiotensin II receptor antagonists, heparin, tacrolimus, cyclosporine; drugs containing cotrimoxazole [trimethoprim + sulfamethoxazole]) may lead to a significant increase in the potassium content in blood plasma. In captopril therapy, potassium-sparing diuretics (for example, triamterene, spironolactone, amiloride, eplerenone), potassium preparations, potassium-containing salt substitutes (contain significant amounts of potassium ions) should be prescribed only with proven hypokalemia, since their use increases the risk of hyperkalemia. Caution should be exercised when co‑prescribing captopril (without or with a diuretic) and drugs that affect the sympathetic nervous system (for example, ganglioblockers, alpha-blockers). NSAIDs, including selective cyclooxygenase‑2 (COX‑2) inhibitors and acetylsalicylic acid in doses of 3 g/day and above, can reduce the antihypertensive effect of diuretics and other antihypertensive agents. ACE inhibitors (C09A) + potassium-sparing diuretics => Severe hypotension, risk of renal failure, hyperkalemia. -
No interactions
The sympathetic nervous system may be particularly important in maintaining blood pressure in patients receiving captopril in monotherapy or in combination with diuretics. -
Positive interactions
In patients taking diuretics, captopril may potentiate the antihypertensive effect. -
Unclear interactions
ACE inhibitors. Hypotension (patients receiving diuretics). Diuretics (e.g. thiazide) can activate the RAAS. Potassium-sparing diuretics, potassium preparations, potassium-containing salt substitutes and other drugs that can increase the potassium content in blood serum.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine