Compatibility «Hyperici perforati herbae extract» and «Sofosbuvir»
Between «Hyperici perforati herbae extract» and «Sofosbuvir» found 2 dangerous and 3 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Sofosbuvir |
✘Hyperici perforati herbae extract Analogs | |
✘Sofosbuvir Analogs |
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Interactions Hyperici perforati herbae extract with Sofosbuvir
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Dangerous interactions
Drugs - powerful inducers of P-gp in the intestine (for example, rifampicin, St. John's wort, carbamazepine and phenytoin) - can lower the plasma concentration of sofosbuvir, leading to a decrease in therapeutic efficacy, therefore they should not be used simultaneously with sofosbuvir (see 'Contraindications' and 'Precautions'). Sofosbuvir should not be used simultaneously with drugs containing St. John's wort, a powerful inducer of P-gp in the intestine. -
Negative interactions
Drugs that are inducers of P-gp in the intestine (for example, rifampicin or St. John's wort) can reduce the concentration of sofosbuvir in blood plasma, leading to a decrease in its therapeutic effect, therefore concomitant use of such drugs with sofosbuvir is not recommended (see 'Precautions'). St. John's wort (Hypericum perforatum) (herbal medicine). The combined use of sofosbuvir and St. John's wort, a P-gp inducer in the intestine, is not recommended. -
Unclear interactions
St. John's wort (Hypericum perforatum).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine