Compatibility «Hyperici perforati herbae extract» and «Warfarin»
Between «Hyperici perforati herbae extract» and «Warfarin» found 3 dangerous and 3 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Warfarin |
✘Hyperici perforati herbae extract Analogs | |
✘Warfarin [Warfarin] Analogs |
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Interactions Hyperici perforati herbae extract with Warfarin
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Dangerous interactions
Simultaneous use with drugs whose metabolism involves cytochrome P450 isoenzymes SUR3A4, SUR2C9, SUR2C19 or drugs transported by P-gp may cause a decrease in their effectiveness: oral coumarin-type anticoagulants (in pm warfarin); drugs used in the treatment of HIV infection; protease inhibitors used in the treatment of viral hepatitis C; immunosuppressants; cytostatic agents (irinotecan, protein kinase inhibitors such as imatinib, periwinkle alkaloids, taxanes, etoposide, cyclophosphamide); other antidepressants. Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics1 (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants1, antidepressants1, intravaginal and systemic antifungal drugs1, antimalarial drugs, antitumor drugs1, antiparasitic and antimicrobial drugs1, platelet aggregation inhibitors, antiteroid drugs1, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics1, drugs that regulate the acidity of gastric juice and anti-ulcer drugs1, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs1, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)1, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins1. Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: steroid inhibitors of the adrenal cortex, antacids, sedatives, antiarrhythmic drugs1, antibiotics1, anticonvulsants1, antidepressants1, antifungal drugs of systemic action1, antihistamines, antitumor drugs1, neuroleptics, antireoid agents1, barbiturates, diuretics1, enteral dietary supplements , enzyme inhibitors, drugs for the regulation of gastric acidity and treatment of peptic ulcer1, hypnotic drugs1, immunosuppressants, lipid-lowering drugs (bile acid sequestrants, HMG-CoA reductase inhibitors)1, drugs of natural origin, oral contraceptives, selective estrogen receptor modulators, adrenocorticosteroids, anti-tuberculosis drugs1, vitamins1. -
Negative interactions
This may lead to a weakening and/or shortening of the duration of the clinical effect of coumarin anticoagulants (for example, phenprocumone, warfarin), immunosuppressants (for example, cyclosporine, sirolimus, tacrolimus), digoxin, indinavir and other protease inhibitors used to treat HIV, irinotecan and other cytostatics, amitriptyline, midazolam, theophylline. - Coenzyme Q10 (ubidecarenone) and St. John's wort are most often associated with a decrease in the effects of warfarin. Some medicinal plants and food products of plant origin (green vegetables such as broccoli) can interact with warfarin through CYP450 (for example, echinacea, grapefruit juice, ginkgo, Canadian hydrastis (Canadian yellowcorn), St. John's wort). -
Unclear interactions
Green vegetables, Canadian yellowcorn (Hydrastis canadensis) (chrysanthemum), white mistletoe (Viscum album), St. John's wort (Hypericum perforatum), yarrow (Achillea millefolium).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine