Compatibility «Clopidogrel» and «Warfarin»
Between «Clopidogrel» and «Warfarin» found 3 dangerous and 1 negative interaction, joint admission is not recommended without consulting a doctor.
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Interactions Clopidogrel with Warfarin
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Dangerous interactions
Due to the possible increased risk of bleeding, caution should be exercised when using clopidogrel and anticoagulants simultaneously, since the tolerability and safety of such a combination have not been established. In patients receiving warfarin for a long time, the use of clopidogrel at a dose of 75 mg / day did not change the pharmacokinetics of S-warfarin (CYP2C9 substrate) or INR, however, simultaneous use of clopidogrel and warfarin increases the risk of bleeding due to its independent effect on hemostasis. Due to the increased risk of bleeding, caution should be exercised when using warfarin and clopidogrel at the same time. -
Negative interactions
Medicinal products of natural origin containing salicylate and/or having antiplatelet properties: agrimony1, aloe gel, aspen poplar (Populus tremuloides), carpal bug (Cimicifuga racemosa), plum-leaved Viburnum (prunifolium), trefoil watch (trifolium)2, cassia4, clove (Eugenia caryophyllus), cranberry, dandelion officinalis4, pyrethrum girlish (tansy girlish) (Chrysanthemum parthenium), garlic5 (Allium sativum), German Sarsaparilla (German Sarsaparilla), sandy sedge (Carex arenaria), ginger, ginkgo biloba, ginseng5 (Panax spp. -
Unclear interactions
Anticoagulants. Warfarin (CYP2C9 substrates). Injectable anticoagulants (heparin). Oral anticoagulants (warfarin). Platelet antiplatelet agents. 1 They contain coumarins, have antiplatelet properties and may have coagulant properties due to the possible content of vitamin K. 4 They contain coumarins and have antiplatelet properties. 5 Have antiplatelet and fibrinolytic properties.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine