Compatibility «Irinotecan» and «Bevacizumab»
Between «Irinotecan» and «Bevacizumab» found 1 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Bevacizumab |
✘Irinotecan Analogs | |
✘Bevacizumab Analogs |
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Interactions Irinotecan with Bevacizumab
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Dangerous interactions
If severe diarrhea, leukopenia or neutropenia develops during combination therapy with bevacizumab and irinotecan, dose adjustment of irinotecan is necessary. -
Negative interactions
In patients with mCRP treated with bevacizumab in combination with IFL, an increase in the concentration of the active metabolite of irinotecan SN38 was noted by 33%, compared with patients treated with IFL alone (the association of an increase in SN38 levels with bevacizumab has not been established). In patients treated with IFL+bevacizumab, an increase in the frequency of adverse events such as diarrhea and leukopenia (known adverse drug reactions of irinotecan) was noted, as well as a more frequent reduction in the dose of irinotecan. -
No interactions
Avastin has no significant effect on the pharmacokinetics of irinotecan and its active metabolite (SN38); capecitabine and its metabolites, as well as oxaliplatin (determined by free and total platinum levels); interferon alpha-2a; cisplatin.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine