Compatibility «Sulfathiazole silver» and «Methotrexate»
Between «Sulfathiazole silver» and «Methotrexate» found 5 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Methotrexate |
✘Sulfathiazole silver Analogs | |
✘Methotrexate Analogs |
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Interactions Sulfathiazole silver with Methotrexate
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Dangerous interactions
Sulfonamides (D06BA) and co-trimoxazole (J01EE01) + Indirect anticoagulants, oral antidiabetic agents, methotrexate => Increased effects and toxic effects of these drugs. Sulfonamides (D06BA) + Anthuran, butadione, indomethacin. methotrexate, salicylates, phenyline => Increased side effects of sulfonamides (leukopenia, neuritis, kidney damage). Methotrexate partially binds to serum albumin and can be displaced from this connection when used simultaneously with drugs that strongly bind to plasma proteins, such as sulfonylureas, aminobenzoic acid, salicylates, phenylbutazone, phenytoin, sulfonamides, some antibiotics (penicillins, tetracycline, pristinamycin, chloramphenicol), probenecid, which can lead to an increase in toxicity of methotrexate. The possibility of increased hepatotoxicity when prescribing methotrexate with other hepatotoxic drugs has not been evaluated. Therefore, patients receiving methotrexate and other potentially hepatotoxic drugs together (for example, leflunomide, azathioprine, sulfasalazine, retinoids) should be closely monitored due to a possible increased risk of hepatotoxicity. -
Negative interactions
Folic acid and its structural analogues (e.g. procaine) can weaken the antimicrobial effect of sulfatiazole. Penicillins and sulfonamides can reduce the renal clearance of methotrexate, hematological and gastrointestinal toxicity has been observed in combination with methotrexate. -
Positive interactions
The increased and prolonged effect of methotrexate, leading to intoxication, is facilitated by the simultaneous use of NSAIDs, barbiturates, sulfonamides, corticosteroids, tetracyclines, trimethoprim, chloramphenicol, paraaminobenzoic and paraaminohippuric acids, probenecid. -
Unclear interactions
Laboratory studies show that various compounds, including sulfonamides, salicylates, tetracyclines, chloramphenicol and phenytoin, can displace methotrexate from binding to plasma albumin. Penicillins and sulfonamides. Hepatotoxic drugs.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine