Compatibility «Sotalol» and «Amlodipine+Indapamide+Perindopril»
Between «Sotalol» and «Amlodipine+Indapamide+Perindopril» found 3 dangerous and 8 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Amlodipine+Indapamide+Perindopril |
✘Sotalol Analogs | |
✘Amlodipine+Indapamide+Perindopril [Amlodipine and more 2Indapamide, Perindopril] Analogs |
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Interactions Sotalol with Amlodipine+Indapamide+Perindopril
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Dangerous interactions
Simultaneous administration of beta-blockers and blockers of 'slow' calcium channels can lead to arterial hypotension, bradycardia, impaired conduction and heart failure. Calcium channel blockers (C08,C08CA) + Class I and III antiarrhythmic drugs (C01B) => Significantly increases the likelihood of ventricular fibrillation. (The combination should be avoided). Indapamide (C03BA11) + Antiarrhythmic drugs (C01B) => Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated). -
Negative interactions
Cardiac glycosides, reserpine, clonidine, alpha-methyldofa, guanfacine potentiate heart rate reduction and inhibition of intracardiac conduction, calcium antagonists block beta-adrenergic receptors, amiodarone - the risk of arrhythmias. Simultaneous use of beta-blockers and blockers of 'slow' calcium channels that suppress myocardial function (for example, verapamil and diltiazem) should be avoided due to the additive effect of these agents on atrioventricular conduction and ventricular function. Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors. Although no negative inotropic effect was usually observed in the study of amlodipine, nevertheless, some BMCC may enhance the severity of the negative inotropic effect of antiarrhythmic agents that cause prolongation of the QT interval (for example, amiodarone and quinidine). Hypotension is enhanced by tricyclic antidepressants, barbiturates, phenothiazine derivatives, narcotic analgesics, haloperidol, vasodilators, diuretics. The use of diuretics of this type can lead to hypokalemia or hypomagnesemia, which increases the likelihood of arrhythmia of the 'pirouette' type. Tricyclic antidepressants, barbiturates, phenothiazines, narcotic and antihypertensive drugs, diuretics and vasodilators can cause a sharp decrease in blood pressure. Perindopril can be used in conjunction with acetylsalicylic acid (as an antiplatelet agent), thrombolytic agents, beta-blockers and/or nitrates. -
No interactions
In patients with stable angina pectoris, amlodipine can be used in combination with other antianginal agents, for example, with prolonged or short-acting nitrates beta-blockers. -
Positive interactions
It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates. -
Unclear interactions
Blockers of 'slow' calcium channels. antiarrhythmic drugs of class III (dofetilide, ibutilide, bretilia tosylate), sotalol, dronedarone, amiodarone;. Acetylsalicylic acid, thrombolytic agents, beta-blockers, nitrates.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine