Compatibility «Omeprazole» and «Methotrexate»
Between «Omeprazole» and «Methotrexate» found 5 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Methotrexate |
✘Omeprazole Analogs | |
✘Methotrexate Analogs |
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Interactions Omeprazole with Methotrexate
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Dangerous interactions
It has been reported that the simultaneous use of certain NSAIDs with high doses of methotrexate increases and prolongs the concentration of methotrexate in serum, which can lead to death from severe hematological (including suppression of bone marrow function and aplastic anemia) and gastrointestinal toxicity. Simultaneous use of proton pump inhibitors and high doses of methotrexate should be avoided, especially in patients with impaired renal function. Data from published population pharmacokinetic studies and reports of reported cases show that the simultaneous use of certain proton pump inhibitors, such as omeprazole, esomeprazole and pantoprazole, with methotrexate (mainly in high doses) can cause an increase and prolongation of the concentration of methotrexate and/or its metabolite hydrometotrexate in serum, which can lead to the development of methotrexate toxicity. The possibility of increased hepatotoxicity when prescribing methotrexate with other hepatotoxic drugs has not been evaluated. Therefore, patients receiving methotrexate and other potentially hepatotoxic drugs together (for example, leflunomide, azathioprine, sulfasalazine, retinoids) should be closely monitored due to a possible increased risk of hepatotoxicity. -
Negative interactions
Clinical cases, published data from population pharmacokinetic studies and retrospective analysis indicate that the simultaneous use of proton pump inhibitors and methotrexate (mainly in high doses) can increase the level of methotrexate and/or its metabolite hydroxymethotrexate in serum and increase the duration of their exposure. However, there have been no official studies of the drug interaction of methotrexate with proton pump inhibitors. Caution should be exercised when prescribing high doses of methotrexate in patients simultaneously receiving proton pump inhibitors. In two of these cases, a delay in methotrexate elimination was observed with the combined use of high doses of methotrexate with a proton pump inhibitor, but was not observed with the combined use of methotrexate with ranitidine. Penicillins and sulfonamides can reduce the renal clearance of methotrexate, hematological and gastrointestinal toxicity has been observed in combination with methotrexate. -
Unclear interactions
Methotrexate. Proton pump inhibitors. Hepatotoxic drugs.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine