Compatibility «Omeprazole» and «Clarithromycin»
Between «Omeprazole» and «Clarithromycin» found 10 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Clarithromycin |
✘Omeprazole Analogs | |
✘Clarithromycin Analogs |
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Interactions Omeprazole with Clarithromycin
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Negative interactions
Concomitant use of omeprazole and voriconazole (a combined CYP2C19 and CYP3A4 inhibitor) resulted in a doubling of omeprazole exposure. Inducers of CYP2C19 or CYP3A4 (such as rifampicin) can lead to a decrease in serum levels of omeprazole. In a cross-sectional study in 12 healthy men, St. John's wort (300 mg 3 times daily for 14 days), a CYP3A4 inducer, reduced systemic exposure of omeprazole in slow (Cmax and AUC decreased by 37.5 and 37.9%, respectively) and fast (Cmax and AUC decreased by 49.6 and 43.9%, respectively) of CYP2C19 metabolizers. The simultaneous use of clarithromycin in double and triple therapy with other drugs can lead to serious side effects due to interaction with clarithromycin. Therefore, clarithromycin is contraindicated for joint use with some drugs. With daily intake of 500 mg of clarithromycin every 8 hours in combination with omeprazole 40 mg in healthy volunteers, the values of the pharmacokinetic parameters of omeprazole increased at steady state: plasma concentration (max'>Cmax) - by 30%, AUC0-24 - by 89%, T1/2 - by 34%. The pH value in the stomach for 24 hours was 5.2 when taking omeprazole alone and 5.5 when taking omeprazole with clarithromycin. With the combined use of clarithromycin and omeprazole, the equilibrium plasma concentrations of omeprazole were increased (Cmax, AUC0-24 and T1/2 increased by 30%, 89% and 34%, respectively). The average pH of the stomach for 24 hours was 5.2 when taking omeprazole alone and 5.7 when taking omeprazole together with clarithromycin. However, there have been reports of increased INR and prothrombin time in patients who were simultaneously taking proton pump inhibitors and warfarin. -
Unclear interactions
Combination therapy with clarithromycin. Omeprazole + Clarithromycin analgin and citramon are used together in Pylobact AM, Pilobact. The metabolism of the following drugs/classes is carried out by the same CYP3A isoenzyme as the metabolism of clarithromycin, for example, alprazolam, carbamazepine, cilostazol, cyclosporine, disopyramide, methylprednisolone, midazolam, omeprazole, indirect anticoagulants (e.g., warfarin), atypical antipsychotics (e.g., quetiapine), quinidine, rifabutin, sildenafil, tacrolimus, triazolam and a vinblastine. Omeprazole. Clarithromycin (500 mg every 8 hours) was studied in healthy adult volunteers in combination with omeprazole (40 mg daily).
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine