Compatibility «Amlodipine» and «Clarithromycin»
Between «Amlodipine» and «Clarithromycin» found 2 dangerous and 8 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Clarithromycin |
✘Amlodipine Analogs | |
✘Clarithromycin Analogs |
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Interactions Amlodipine with Clarithromycin
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Dangerous interactions
Patients taking clarithromycin and amlodipine at the same time have an increased risk of lowering blood pressure. Calcium channel blockers(C08) + Macrolides and azalides (J01FA) => Significantly increases the likelihood of ventricular fibrillation. (The combination is contraindicated). -
Negative interactions
This result was not observed in individuals who did not express CYP3A5 (n=6). However, a 3-fold increase in plasma exposure to tacrolimus was reported in a kidney transplant patient (non-CYP3A5 expressor) after starting amlodipine for the treatment of post-transplant hypertension, which led to a decrease in the dose of tacrolimus. Regardless of the status of the CYP3A5 genotype, the possibility of interaction with these drugs cannot be excluded. Inhibitors of the CYP3A4 isoenzyme. Clarithromycin is an inhibitor of the CYP3A4 isoenzyme. Since amlodipine is a weak inhibitor of CYP3A4, the exposure of mTOR inhibitors may increase when used together. When using clarithromycin and blockers of 'slow' calcium channels, which are metabolized by the CYP3A4 isoenzyme (for example, verapamil, amlodipine, diltiazem), caution should be exercised, since there is a risk of arterial hypotension. As well as blockers of 'slow' calcium channels, they can increase with simultaneous use. -
Positive interactions
A prospective study involving healthy volunteers from China (n=9), CYP3A5 expressers, showed an increase in tacrolimus exposure by 2.5-4 times when used concomitantly with amlodipine compared with the use of tacrolimus alone. -
Unclear interactions
However, strong CYP3A inhibitors (e.g., itraconazole, clarithromycin) can increase plasma concentrations of amlodipine to a greater extent. Clarithromycin. Blockers of 'slow' calcium channels.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine