Compatibility «Phenobarbital» and «Lamotrigine»
Between «Phenobarbital» and «Lamotrigine» found 1 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Lamotrigine |
✘Phenobarbital Analogs | |
✘Lamotrigine Analogs |
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Interactions Phenobarbital with Lamotrigine
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Dangerous interactions
When used simultaneously with other drugs that depress the central nervous system (in pm sedatives, hypnotics, some antihistamines, anxiolytics), and alcohol, an additive depressive effect is possible. -
Negative interactions
The same effects are observed when taken simultaneously with other CNS depressants. A gradual transient increase in the concentration of lamotrigine in blood plasma (approximately a 2-fold increase) occurred during a week without pills in women who also did not take drugs that increase lamotrigine clearance (carbamazepine, phenytoin, phenobarbital, primidone or other drugs such as rifampicin and protease inhibitors lopinavir + ritonavir and atazanavir + ritonavir, inducing glucuronidation of lamotrigine). Limited clinical data indicate a higher incidence of dizziness, diplopia, ataxia and blurred vision in patients receiving carbamazepine and lamotrigine together than in patients receiving other antiepileptic drugs with lamotrigine. The combined use of phenobarbital or primidone reduces ss'>Css lamotrigine in blood plasma by approximately 40%. -
Unclear interactions
Antiepileptic drugs - carbamazepine, lamotrigine, thiagabine, zonisamide, primidone and possibly ethosuximide;. Phenobarbital/primidone. Phenobarbital, primidone.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine