Compatibility «Enalapril» and «Fosinopril»
Between «Enalapril» and «Fosinopril» found 4 dangerous and 5 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Fosinopril |
✘Enalapril Analogs | |
✘Fosinopril Analogs |
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Interactions Enalapril with Fosinopril
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Dangerous interactions
Like other drugs that affect sodium excretion, ACE inhibitors can reduce lithium excretion by the kidneys and lead to increased cardiotoxic and neurotoxic effects of lithium. Concomitant use of ACE inhibitors with drugs containing aliskiren is contraindicated in patients with diabetes mellitus and/or with moderate or severe renal insufficiency (GFR less than 60 ml/min/1.73 m2 body surface area) and is not recommended in other patients. Concomitant use of ACE inhibitors with angiotensin II receptor antagonists (ARA II) is contraindicated in patients with diabetic nephropathy and is not recommended in other patients. In patients with chronic heart failure, diabetes mellitus, who simultaneously take potassium-sparing diuretics, potassium, potassium-containing salt substitutes or other agents that cause hyperkalemia (for example, heparin), ACE inhibitors increase the risk of hyperkalemia. -
Negative interactions
However, other studies suggest that NSAIDs may reduce the antihypertensive effect of ACE inhibitors. NSAIDs, including selective COX‑2 inhibitors and acetylsalicylic acid in doses of 3 g/day and above, can reduce the antihypertensive effect of diuretics and other antihypertensive agents. Enalapril and Fosinopril belong to the same pharmaceutical group: ACE inhibitors. The effect is enhanced (additive effect) by other antihypertensive agents, including beta-blockers, in PM in ophthalmic dosage forms with significant systemic absorption, diuretics, alcohol. It is known that indomethacin and other nonsteroidal anti‑inflammatory drugs (NSAIDs), in pm selective cyclooxygenase‑2 (COX-2) inhibitors and acetylsalicylic acid at a dose exceeding 3 g per day, can reduce the antihypertensive effect of ACE inhibitors, especially in patients with low-grade hypertension. -
Positive interactions
When using enalapril simultaneously with other antihypertensive agents, especially with diuretics, an increased antihypertensive effect may be observed. It is a synergist of peripheral vasodilators (minoxidil, etc.).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine