Compatibility «Enalapril» and «Verospiron»
Between «Enalapril» and «Verospiron» found 6 dangerous and 11 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Verospiron |
✘Enalapril Analogs | |
✘Verospiron [Spironolactone] Analogs |
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Interactions Enalapril with Verospiron
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Dangerous interactions
In patients receiving diuretics, especially with the recent appointment of diuretic therapy, there may be an excessive decrease in blood pressure after the start of enalapril. In the elderly, patients with hypovolemia (including those receiving diuretics) or impaired renal function, the simultaneous use of enalapril and NSAIDs, including selective COX-2 inhibitors, may lead to deterioration of renal function, including the development of acute renal failure. The excessive antihypertensive effect of enalapril can be reduced either by discontinuing the diuretic, or by increasing the BCC or using table salt, as well as by reducing the dose of enalapril. In some patients with impaired renal function (for example, in elderly patients or patients with dehydration, including those taking diuretics) receiving NSAID therapy (including selective COX‑2 inhibitors), the simultaneous use of ACE inhibitors or ARA II may cause further deterioration of renal function, including the development of acute renal failure, and hyperkalemia. Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia. Since ACE inhibitors reduce the production of aldosterone, drugs of this group should not be used in conjunction with spironolactone on a regular basis, especially in patients with established renal dysfunction. -
Negative interactions
The possibility of hypotensive effects when using enalapril can be minimized by stopping the diuretic or increasing salt intake before starting treatment with enalapril. If it is necessary to continue taking a diuretic, careful medical monitoring should be provided after taking the initial dose for at least 2 hours and one additional hour before blood pressure stabilizes. The antihypertensive effect of enalapril is enhanced by drugs that cause the release of renin (for example, diuretics). The use of potassium-sparing diuretics (for example, spironolactone, triamterene or amiloride), additional intake of potassium or potassium-containing salt substitutes can lead to a significant increase in serum potassium levels. Concomitant use of enalapril with potassium-sparing diuretics (such as spironolactone, eplerenone, triamterene, amiloride), potassium preparations, potassium-containing salt substitutes and other drugs capable of increasing serum potassium content (including angiotensin II receptor antagonists, heparin, tacrolimus, cyclosporine; drugs containing co‑trimoxazole [trimethoprim + sulfamethoxazole]) can lead to a significant increase in the potassium content in blood plasma. The use of potassium-sparing diuretics in high doses can lead to hypovolemia (due to a decrease in BCC), and the addition of enalapril to therapy leads to a marked decrease in blood pressure. With the simultaneous use of enalapril with potassium-sparing (thiazide or 'loop') diuretics, hypokalemia caused by the action of diuretics, as a rule. NSAIDs, including selective COX‑2 inhibitors and acetylsalicylic acid in doses of 3 g/day and above, can reduce the antihypertensive effect of diuretics and other antihypertensive agents. ACE inhibitors (C09A) + potassium-sparing diuretics => Severe hypotension, risk of renal failure, hyperkalemia. Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia. Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary. -
Positive interactions
When using enalapril simultaneously with other antihypertensive agents, especially with diuretics, an increased antihypertensive effect may be observed. -
Unclear interactions
Diuretics. Potassium-sparing diuretics, potassium preparations, potassium-containing salt substitutes and other drugs that can increase the potassium content in blood serum. ACE inhibitors.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,972,605 possible combinations of drugs and their components were found 412,508 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-04-11
Category - medicine