Compatibility «Fluoxetine» and «Clozapine»
Between «Fluoxetine» and «Clozapine» found 1 dangerous and 2 negative interactions, joint admission is not recommended without consulting a doctor.
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Interactions Fluoxetine with Clozapine
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Dangerous interactions
When used concomitantly with fluoxetine, paroxetine, sertraline, fluvoxamine, it is possible to increase the concentration of clozapine in blood plasma, which in some patients is accompanied by manifestations of toxicity. -
Negative interactions
The simultaneous use of fluoxetine and other drugs metabolized by CYP2D6, including some antidepressants (e.g. tricyclic antidepressants), neuroleptics (e.g. phenothiazines and most atypical neuroleptics) and antiarrhythmic drugs (e.g. propafenone, flecainide), should be approached with caution. In patients receiving clozapine simultaneously with fluvoxamine, an inhibitor of CYP3A4 and CYP1A2 isoenzymes, an increase in the concentration of the former in blood plasma (up to 10 times) or other selective serotonin reuptake inhibitors, such as paroxetine (inhibitor of CYP1A2 and CYP2D6 isoenzymes), sertraline (inhibitor of CYP2C8/9 and CYP2D6 isoenzymes), fluoxetine ( inhibitor CYP2D6 isoenzyme, increased up to 2 times) or citalopram (possibly a weak inhibitor of the CYP1A2 isoenzyme, which most likely has the weakest ability among all serotonin reuptake inhibitors, causing the development of clinically significant interaction). -
Positive interactions
Increased levels of haloperidol and clozapine in the blood were observed in patients taking fluoxetine at the same time. -
Unclear interactions
Neuroleptics. Some clinical data suggest possible FDV and/or FCV of SSRIs and neuroleptics. These include specific neuroleptics (for example, ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol), specific antibiotics (for example, erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), class IA antiarrhythmic agents (for example, quinidine, procainamide), class III antiarrhythmic agents (for example, amiodarone, sotalol) and others (for example, pentamidine, levomethadyl acetate, methadone, halophantrine, mefloquine, dolacetron mesylate, probucol or tacrolimus).
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine