Compatibility «Verospiron» and «Triplixam»
Between «Verospiron» and «Triplixam» found 15 dangerous and 19 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Triplixam |
✘Verospiron [Spironolactone] Analogs | |
✘Triplixam [Amlodipine+Indapamide+Perindopril and more 3Amlodipine, Indapamide, Perindopril] Analogs |
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Interactions Verospiron with Triplixam
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Dangerous interactions
Lithium-containing drugs, as a rule, should not be prescribed with diuretics. Diuretics reduce the renal clearance of lithium, increasing its concentration in blood plasma and the risk of its toxicity. Diuretics reduce the renal clearance of lithium and increase the risk of developing toxic effects of lithium preparations. In chronic heart failure, treatment with ACE inhibitors should begin with the lowest doses, with a possible preliminary reduction in doses of diuretics. Functional renal insufficiency, which can occur against the background of taking diuretics, especially 'loop' ones, while prescribing metformin increases the risk of lactic acidosis. Dehydration of the body while taking diuretic drugs increases the risk of acute renal failure, especially when using high doses of iodine-containing contrast agents. Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia. Since ACE inhibitors reduce the production of aldosterone, drugs of this group should not be used in conjunction with spironolactone on a regular basis, especially in patients with established renal dysfunction. Patients taking diuretics, especially those who have recently started treatment, may sometimes experience an excessive decrease in blood pressure after starting therapy with perindopril erbumin. The use of a diuretic may further increase the risk of lithium toxicity. In the elderly, patients with insufficient BCC (in pm receiving diuretic therapy) or with impaired renal function, the combined use of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including perindopril, may lead to deterioration of renal function, including possible acute renal failure. Some drugs or drugs of other pharmacological classes may increase the risk of hyperkalemia: aliskiren and aliskiren‑containing drugs, potassium salts, potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists (ARA II), heparin, immunosuppressants such as cyclosporine or tacrolimus, trimethoprim, drugs containing co-trimoxazole (trimethoprim + sulfamethoxazole). In patients receiving diuretics, especially with excessive excretion of fluid and / or electrolytes, at the beginning of perindopril therapy, an excessive decrease in blood pressure may be observed, the risk of which can be reduced by discontinuing the diuretic, replenishing fluid loss (intravenous infusion of 0.9% sodium chloride solution), as well as using perindopril in lower doses. Spironolactone and eplerenone in doses of 12.5 mg to 50 mg per day for CHF and low doses of ACE inhibitors: when treating CHF of functional class II-IV according to the NYHA classification with a left ventricular ejection fraction less than 40; and previously used ACE inhibitors and 'loop' diuretics, there is a risk of hyperkalemia (possibly fatal), especially in case of non-compliance with the recommendations regarding this combination of drugs. When using diuretics in the case of CHF, an ACE inhibitor should be prescribed at a low dose, possibly after reducing the dose of a potassium-sparing diuretic used simultaneously. -
Negative interactions
In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, with the simultaneous use of spironolactone and NSAIDs, it is necessary to closely monitor the patient to determine whether the desired effect of the diuretic is achieved. Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary. Nonsteroidal anti-inflammatory drugs (NSAIDs): In some patients, NSAIDs may reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Thus, while taking spironolactone with NSAIDs, the patient's condition should be carefully monitored to achieve the desired effect of the diuretic drug. Lithium preparations: as a rule, lithium preparations should not be used in conjunction with diuretics. Carbamazepine: when used concomitantly with diuretics, the drug may cause clinically significant hyponatremia. If necessary, diuretic drugs can be used in combination with lithium preparations, while carefully selecting the dose of drugs, regularly monitoring the concentration of lithium in blood plasma and selecting the dose of the drug accordingly. Patients with arterial hypertension and possibly reduced sodium content in blood plasma due to taking diuretics should:. 3 days before the start of treatment with an ACE inhibitor, stop taking diuretics; in the future, if necessary, taking a non-potassium-sparing diuretic can be resumed;. if discontinuation of diuretics is not possible, then ACE inhibitor therapy should be started at low doses, followed by a gradual increase in the dose if necessary. If simultaneous use of indapamide with potassium-sparing diuretics is necessary, then the potassium content in blood plasma, ECG readings should be monitored and, if necessary, therapy should be adjusted. Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia. However, the bioavailability of perindoprilate was reduced by diuretics, which was associated with a decrease in ACE inhibition in plasma. The use of potassium-sparing diuretics (in pm spironolactone, amiloride, triamterene), potassium supplements or other drugs capable of increasing serum potassium levels (in pm indomethacin, heparin, cyclosporine) may increase the risk of hyperkalemia. The combined use of ACE inhibitors and potassium-sparing diuretics (for example, spironolactone, triamterene, amiloride, eplerenone (a derivative of spironolactone)), potassium preparations and potassium-sparing products and dietary supplements can lead to a significant increase in serum potassium. In patients receiving diuretics that remove fluid and / or salts, at the beginning of Perindopril therapy, there may be a marked decrease in blood pressure, the risk of which can be reduced by discontinuing diuretics, replenishing the loss of fluid or salts before starting Perindopril therapy, as well as using Perindopril at a low dose with a further gradual increase. In hypertension in patients receiving diuretics, especially those that remove fluid and/or salts, diuretics should either be discontinued before the use of an ACE inhibitor (while a potassium-sparing diuretic may be prescribed again later), or an ACE inhibitor should be prescribed at a low dose with a further gradual increase. ACE inhibitors (C09A) + potassium-sparing diuretics => Severe hypotension, risk of renal failure, hyperkalemia. -
No interactions
The simultaneous use of indapamide with potassium-sparing diuretics is advisable in some patients. Concomitant diuretics do not affect the rate and degree of absorption and excretion of perindopril. -
Positive interactions
Simultaneous use of other diuretics: increased diuresis. -
Unclear interactions
Potassium-sparing diuretics (amiloride, spironolactone, triamterene). ACE inhibitors. Diuretics. Potassium supplements and potassium-sparing diuretics. Potassium-sparing diuretics, potassium preparations and potassium-containing products and dietary supplements. Potassium-containing diuretics (eplerenone, spironolactone). Potassium-sparing diuretics.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine