Compatibility «Амлодипин Кардио» and «Viatayl»

• Interactions Амлодипин Кардио with Viatayl

  • Negative interactions
    • ⓘ With the simultaneous use of sildenafil with amlodipine, monitoring is necessary to detect signs of arterial hypotension.
    • ⓘ There were no signs of interaction with amlodipine (5 and 10 mg): an average additional decrease in blood pressure in the supine position (sAD by 8 mmHg.
    • ⓘ When studying the interaction of sildenafil (100 mg) with amlodipine in patients with arterial hypertension, an additional decrease in sAD and dAD in the supine position by 8 and 7 mmHg was noted.
  • No interactions
    • ⓘ The combined use of cimetidine, antacids containing magnesium and aluminum hydroxide, sildenafil and grapefruit juice does not affect the exposure of amlodipine.
    • ⓘ A single dose of 100 mg of sildenafil in patients with essential hypertension has no effect on the pharmacokinetics of amlodipine.
    • ⓘ CYP2C9 inhibitors (tolbutamide, warfarin), CYP2D6 (selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazides and thiazide-like diuretics, loop and potassium-sparing diuretics, ACE inhibitors, calcium antagonists, beta-blockers and cytochrome P450 inducers (rifampicin, barbiturates) have no effect on pharmacokinetics of sildenafil.
  • Positive interactions
    • ⓘ When amlodipine and sildenafil were used in combination, each independently had its own effect of lowering blood pressure.
  • Unclear interactions
    • ⓘ Sildenafil.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,990,749 possible combinations of drugs and their components were found 412,526 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-11-07

Category - medicine