Compatibility «Zyllt» and «Эзомепразол магния дигидрат»
Between «Zyllt» and «Эзомепразол магния дигидрат» found 2 dangerous and 3 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Эзомепразол магния дигидрат |
✘Zyllt [Clopidogrel] Analogs | |
✘Эзомепразол магния дигидрат [Esomeprazol] Analogs |
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Interactions Zyllt with Эзомепразол магния дигидрат
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Dangerous interactions
There is a potential increased risk of gastrointestinal bleeding when used concomitantly with NSAIDs. In the course of observations and clinical studies, contradictory data have been obtained on the presence or absence of an increased risk of cardiovascular complications, nevertheless, clopidogrel should be used with caution in conjunction with esomeprazole. -
Negative interactions
The effect of the active metabolite and platelet inhibition in the combined use of clopidogrel and proton pump inhibitors. If necessary, the use of a proton pump inhibitor with a lower ability to inhibit the activity of CYP2C19, such as pantoprazole, should be considered. There was a pharmacokinetic/pharmacodynamic interaction between clopidogrel (loading dose of 300 mg, followed by a maintenance dose of 75 mg/day) and esomeprazole (40 mg/day), which led to a decrease in exposure to the active metabolite of clopidogrel by an average of 40% and a decrease in the maximum inhibition of ADP-induced platelet aggregation by an average of 14%. -
No interactions
Some non-randomized observational studies have shown that the simultaneous use of clopidogrel and proton pump inhibitors was associated with a higher incidence of adverse cardiovascular events, however, according to randomized clinical trials, no significant association was observed. -
Unclear interactions
Proton pump inhibitors. CYP2C19 inhibitors include, but are not limited to omeprazole, esomeprazole, lansoprazole, cimetidine, ticlopidine, fluvoxamine, fluoxetine, moclobemide, felbamate, chloramphenicol, ketoconazole.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine