Compatibility «Amlodipine+Atorvastatin» and «Allergenum e farina et granula cibaria»
Between «Amlodipine+Atorvastatin» and «Allergenum e farina et granula cibaria» found 2 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Allergenum e farina et granula cibaria |
✘Amlodipine+Atorvastatin [Amlodipine and more 1Atorvastatin] Analogs | |
✘Allergenum e farina et granula cibaria [Proteine] Analogs |
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Interactions Amlodipine+Atorvastatin with Allergenum e farina et granula cibaria
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Negative interactions
Due to the dual mechanism of interaction with rifampicin (an inducer of the CYP3A4 isoenzyme and an inhibitor of the hepatocyte transport protein OATP1B1), simultaneous use of atorvastatin and rifampicin is recommended, since delayed administration of atorvastatin after taking rifampicin leads to a significant decrease in the concentration of atorvastatin in blood plasma. Cyclosporine is an inhibitor of OATP1B1, OATP1B3, multidrug resistance protein (MDR1) and BCRP, as well as CYP3A4, therefore it increases the exposure of atorvastatin. -
No interactions
Amlodipine does not affect in vitro the degree of binding to plasma proteins of digoxin, phenytoin, warfarin and indomethacin. In vitro data show that amlodipine does not affect the binding of digoxin, phenytoin, warfarin and indomethacin to human plasma proteins. In vitro studies, amlodipine did not affect the binding of digoxin to plasma proteins. In vitro studies, amlodipine did not affect the binding of warfarin to plasma proteins. In vitro studies, amlodipine did not affect the binding of phenytoin to plasma proteins. In vitro studies, amlodipine did not affect the binding of indomethacin to plasma proteins. -
Unclear interactions
Inhibitors of the OATR1B1 transport protein. Atorvastatin and its metabolites are substrates of the OATP1B1 transport protein.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
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Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine