Compatibility «Co-Diroton» and «Allopurinol-Egis»
Between «Co-Diroton» and «Allopurinol-Egis» found 3 dangerous and 4 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Allopurinol-Egis |
✘Co-Diroton [Lisinopril and more 1Hydrochlorothiazide] Analogs | |
✘Allopurinol-Egis [Allopurinol] Analogs |
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Interactions Co-Diroton with Allopurinol-Egis
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Dangerous interactions
Concomitant use of ACE inhibitors with allopurinol is accompanied by an increased risk of leukopenia, so these drugs should be combined with caution. An increased risk of hypersensitivity has been reported when allopurinol was used with ACE inhibitors, especially in renal failure. Concomitant use of thiazide diuretics, in pm and hydrochlorothiazide, may increase the risk of hypersensitivity side effects associated with allopurinol, especially in patients with impaired renal function. -
Negative interactions
Allopurinol, procainamide, cytostatics, immunosuppressants, GCS (with systemic use). The combined use of ACE inhibitors with allopurinol, procainamide, and cytostatics increases the risk of neutropenia/agranulocytosis. It may be necessary to adjust the dose of uricosuric drugs, since hydrochlorothiazide increases the concentration of uric acid in the blood serum. Thiazide diuretics may increase the frequency of hypersensitivity reactions to allopurinol. Pyrazinamide, salicylates, uricosuric agents, thiazide diuretics, furosemide, ethacric acid weaken the hypouricemic effect. -
Unclear interactions
ACE inhibitors. Medications used to treat gout (probenecid, sulfinpyrazone, allopurinol). Diuretics.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine