Compatibility «Vortioxetine» and «Fluconazole»
Between «Vortioxetine» and «Fluconazole» found 2 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Fluconazole |
| ✘Vortioxetine Analogs | |
| ✘Fluconazole Analogs |
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Interactions Vortioxetine with Fluconazole
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Negative interactions
- Addition of vortioxetine 6 days after the start of ketoconazole at a dose of 400 mg/day (inhibitor of CYP3A4/5 and P-gp isoenzymes) or 6 days after the start of fluconazole at a dose of 200 mg/day (inhibitor of CYP2C9, CYP2C19 and CYP3A4/5 isoenzymes) in healthy subjects, vortioxetine exposure (AUC) increased 1.3 and 1.5 times, respectively.
- Special studies of the use of vortioxetine simultaneously with strong inhibitors of the CYP3A4 isoenzyme (such as itraconazole, voriconazole, clarithromycin, telithromycin, nefazodone, conivaptan and many HIV protease inhibitors) and inhibitors of the CYP2C9 isoenzyme (such as fluconazole and amiodarone) in patients with reduced activity of the CYP2D6 isoenzyme (see 'Pharmacokinetics'), it has not been performed, nevertheless, it can be expected that in these patients such use will lead to a more pronounced exposure to vortioxetine compared with the moderate effect described above.
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Negative interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-12-19
Category - medicine