Compatibility «Amlodipine+Lisinopril+Rosuvastatin» and «Fluconazole»

• Interactions Amlodipine+Lisinopril+Rosuvastatin with Fluconazole

  • Dangerous interactions
    • ⓘ When fluconazole is co-administered with HMG-CoA reductase inhibitors metabolized by the CYP3A4 isoenzyme (such as atorvastatin and simvastatin) or the CYP2D6 isoenzyme (such as fluvastatin (decreased liver metabolism of statins)), the risk of myopathy and rhabdomyolysis increases (depending on the dose).
    • ⓘ In case of an increase in creatinine kinase concentration or if myopathy or rhabdomyolysis is diagnosed or suspected, therapy with HMG-CoA reductase inhibitors should be discontinued.
  • Negative interactions
    • ⓘ Fluconazole increases the systemic exposure of calcium channel antagonists.
    • ⓘ Concomitant administration of fluconazole led to an increase in the AUC of rosuvastatin by 14%.
    • ⓘ Lower doses of HMG-CoA reductase inhibitors may be required, as indicated in the instructions for the medical use of statins.
  • No interactions
    • ⓘ There was no clinically significant interaction between rosuvastatin and fluconazole (an inhibitor of CYP2C9 and CYP3A4 isoenzymes) and ketoconazole (an inhibitor of CYP2A6 and CYP3A4 isoenzymes).
    • ⓘ Fluconazole (200 mg 1 time per day, 11 days) + rosuvastatin (80 mg once) - unchanged.
  • Positive interactions
    • ⓘ An increase in the incidence of myositis and myopathy was observed in patients receiving other HMG-CoA reductase inhibitors simultaneously with cyclosporine, fibroic acid derivatives (including gemfibrozil), nicotinic acid, azole antifungal drugs and macrolide antibiotics.
  • Unclear interactions
    • ⓘ Fluconazole may increase the systemic effects of certain BCC (nifedipine, isradipine, amlodipine, felodipine), which are metabolized with the participation of CYP3A4.
    • ⓘ Blockers of 'slow' calcium channels.
    • ⓘ Some calcium channel antagonists (nifedipine, isradipine, amlodipine, verapamil and felodipine) are metabolized by the CYP3A4 isoenzyme.
    • ⓘ This has been confirmed in studies with known inhibitors of CYP2C9, CYP2C19 and CYP3A (ketoconazole, fluconazole).
    • ⓘ Fluconazole.
    • ⓘ HMG-CoA reductase inhibitors.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine