Compatibility «Alcohol (ethanol)» and «Brimonidine+Timolol»

• Interactions Alcohol (ethanol) with Brimonidine+Timolol

  • Dangerous interactions
    • ⓘ Nevertheless, one should take into account the possibility of enhancing the effect of drugs that depress the central nervous system (alcohol, barbiturates, opium derivatives, sedatives, general anesthetics), when used simultaneously with a combination of brimonidine + timolol.
    • ⓘ Timolol may exacerbate compensatory tachycardia and increase the risk of a marked decrease in blood pressure when used with general anesthetics.
    • ⓘ The combined use of beta-blockers with drugs for general anesthesia may conceal compensatory tachycardia and increase the risk of a pronounced decrease in blood pressure, therefore, the anesthesiologist should be warned about the use of the combination brimonidine + timolol by the patient.
    • ⓘ anesthetics (N01A) + Alpha-adrenomimetics; Beta-adrenomimetics (R03CA, R03DB, S01EA) => Joint use is contraindicated due to the possible development of life-threatening cardiac arrhythmias.
    • ⓘ However, with its simultaneous use, the possibility of enhancing the effect of drugs that depress the central nervous system (alcohol, barbiturates, opioids, sedatives, general anesthetics) should be taken into account.
    • ⓘ Alpha-adrenomimetics; Beta-adrenomimetics (R03CA, R03DB, S01EA) + anesthetics (N01A) => Combined use is not recommended, as life-threatening cardiac arrhythmias may develop.
    • ⓘ beta-blockers (C07) + Drugs for inhalation anesthesia (fluorotane, ether for anesthesia) => Bradycardia, arterial hypotension, bronchospasm, possible cardiac arrest.
    • ⓘ beta-blockers (C07) + CNS depressants (neuroleptics — phenothiazine and butyrophenone derivatives, benzodiazepine tranquilizers, hypnotics) => Bradycardia, respiratory depression, possibly comatose state.
  • Negative interactions
    • ⓘ Ethanol + b-Adrenoblockers => Increased depressive effect of b-adrenoblockers on the heart.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
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  • See the compatibility of drugs with alcohol (enter it as a drug).
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine