Compatibility «Indapamide» and «Amlodipine+Lisinopril»

• Interactions Indapamide with Amlodipine+Lisinopril

  • Dangerous interactions
    • ⓘ Calcium channel blockers(C08) + Drugs that cause hypokalemia; Glucocorticosteroids (C03A, A01AB04,J02AA01,H02,D07 => Increases the likelihood of ventricular tachycardia and ventricular fibrillation. (A dangerous combination, it is necessary to eliminate hypokalemia before use).
    • ⓘ The administration of ACE inhibitors to patients with hyponatremia (especially patients with renal artery stenosis) is accompanied by a risk of developing sudden arterial hypotension and/or acute renal failure.
    • ⓘ In chronic heart failure, treatment with ACE inhibitors should begin with the lowest doses, with a possible preliminary reduction in doses of diuretics.
    • ⓘ Starting lisinopril in patients taking diuretics may lead to an excessive decrease in blood pressure.
    • ⓘ In the elderly, patients with reduced BCC (in pm receiving diuretic therapy) or impaired renal function, the co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including lisinopril, may lead to deterioration of renal function, including possible acute renal failure.
  • Negative interactions
    • ⓘ Lisinopril reduces the calyuretic effect of diuretics.
    • ⓘ Other antihypertensive drugs.
    • ⓘ As monotherapy, amlodipine was well combined with thiazide and loop diuretics, general anesthesia agents, beta-blockers, ACE inhibitors, long-acting nitrates, nitroglycerin, digoxin, warfarin, atorvastatin, sildenafil, antacid drugs (aluminum hydroxide, magnesium hydroxide), simeticone, cimetidine, NSAIDs, antibiotics and hypoglycemic agents for oral administration.
    • ⓘ Other antihypertensive and antianginal drugs.
    • ⓘ Amlodipine can be safely used to treat hypertension together with thiazide diuretics, beta-blockers or ACE inhibitors.
    • ⓘ The use of indapamide can sum up or potentiate the effect of other antihypertensive drugs.
    • ⓘ In limited controlled studies comparing the effects of indapamide in combination with other antihypertensive drugs with the effects of other antihypertensive drugs used as monotherapy, there were no noticeable changes in the nature or frequency of adverse reactions associated with combination therapy.
    • ⓘ 3 days before the start of treatment with an ACE inhibitor, stop taking diuretics; in the future, if necessary, taking a non-potassium-sparing diuretic can be resumed;.
    • ⓘ if discontinuation of diuretics is not possible, then ACE inhibitor therapy should be started at low doses, followed by a gradual increase in the dose if necessary.
    • ⓘ In all cases, in the first week of taking ACE inhibitors in patients, it is necessary to monitor renal function (creatinine concentration in blood plasma).
    • ⓘ Blood pressure should be monitored and, if necessary, the doses of antihypertensive drugs should be adjusted.
    • ⓘ The possibility of hypotensive effects when taking lisinopril can be minimized by reducing or stopping the diuretic or increasing salt intake before starting treatment with lisinopril.
    • ⓘ Lisinopril attenuates potassium loss caused by thiazide-type diuretics.
    • ⓘ When used simultaneously with vasodilators, beta-blockers, BMCC, diuretics and other antihypertensive drugs, the severity of the antihypertensive effect of lisinopril increases.
    • ⓘ Blood pressure should be carefully monitored and, if necessary, the dose of antihypertensive drugs should be adjusted.
  • Positive interactions
    • ⓘ In the case of the use of diuretics against the background of therapy with a combination of amlodipine + lisinopril, the antihypertensive effect is usually enhanced.
    • ⓘ It is possible to enhance the antianginal and antihypertensive effects of BCC when used simultaneously with thiazide and loop diuretics, verapamil, ACE inhibitors, beta-blockers, nitrates and other vasodilators, as well as to enhance their antihypertensive effect when used simultaneously with alpha-blockers, neuroleptics.
    • ⓘ It is possible to enhance the antianginal and antihypertensive effects of BMCC when combined with thiazide and loop diuretics, ACE inhibitors, beta-blockers and nitrates.
  • Unclear interactions
    • ⓘ Diuretics.
    • ⓘ Amlodipine + Indapamide analgin and citramon are used together in 4 preparations.
    • ⓘ Lisinopril + Indapamide analgin and citramon are used together in Diroton Plus, Эквапресс.
    • ⓘ If it is necessary to continue taking a diuretic, the initial dose of lisinopril should be reduced.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine