Compatibility «Esomeprazol» and «Dexamethasone»

• Interactions Esomeprazol with Dexamethasone

  • Dangerous interactions
    • ⓘ Reduce the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), enhance - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin In and carbonic anhydrase inhibitors, the risk of erosive ulcerative lesions and bleeding from the gastrointestinal tract - NSAIDs.
    • ⓘ Since stomach ulcers and gastrointestinal bleeding have been reported in patients taking deferasirox, caution should be exercised when prescribing it with other drugs that are known to increase the risk of peptic ulcer or gastric bleeding, including GCS.
  • Negative interactions
    • ⓘ The combined oral administration of esomeprazole and clarithromycin, an inhibitor of the CYP3A4 isoenzyme (500 mg 2 times a day), leads to a twofold increase in the AUC of esomeprazole.
    • ⓘ Concomitant use of esomeprazole and a combined inhibitor of CYP3A4 and CYP2C19 isoenzymes, for example voriconazole, can lead to an increase in the AUC of esomeprazole up to 280%.
    • ⓘ Drugs that induce CYP2C19 and CYP3A4 isoenzymes, such as rifampicin and St. John's wort preparations, when used concomitantly with esomeprazole, can lead to a decrease in the concentration of esomeprazole in blood plasma by accelerating its metabolism.
    • ⓘ If simultaneous use of dexamethasone (a moderate CYP3A4 inducer) is necessary, it is necessary to monitor the decrease in the effectiveness of esomeprazole (CY2C19 and CYP3A4 substrate).
  • Unclear interactions
    • ⓘ The isoenzymes CYP2C19 and CYP3A4 are involved in the metabolism of esomeprazole.
    • ⓘ Esomeprazole.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine