Compatibility «Celecoxib» and «Methotrexate»

• Interactions Celecoxib with Methotrexate

  • Dangerous interactions
    • ⓘ With the simultaneous use of NSAIDs and methotrexate, the toxic effect of methotrexate increases (for example, neutropenia, thrombocytopenia, impaired renal function).
    • ⓘ With the simultaneous use of celecoxib and methotrexate, it is recommended to monitor the condition of patients for the development of methotrexate toxicity.
    • ⓘ NSAIDs should not be prescribed before or simultaneously with high doses of methotrexate.
    • ⓘ It has been reported that the simultaneous use of certain NSAIDs with high doses of methotrexate increases and prolongs the concentration of methotrexate in serum, which can lead to death from severe hematological (including suppression of bone marrow function and aplastic anemia) and gastrointestinal toxicity.
    • ⓘ Animal studies have shown that NSAIDs reduce the tubular secretion of methotrexate and can increase its toxicity by increasing the concentration of methotrexate in the blood.
    • ⓘ The possibility of increased hepatotoxicity when prescribing methotrexate with other hepatotoxic drugs has not been evaluated.
    • ⓘ Therefore, patients receiving methotrexate and other potentially hepatotoxic drugs together (for example, leflunomide, azathioprine, sulfasalazine, retinoids) should be closely monitored due to a possible increased risk of hepatotoxicity.
  • Negative interactions
    • ⓘ Concomitant use of celecoxib and pemetrexed may increase the risk of myelosuppression, renal and gastrointestinal toxicity associated with the action of pemetrexed.
    • ⓘ The increased and prolonged effect of methotrexate, leading to intoxication, is facilitated by the simultaneous use of NSAIDs, barbiturates, sulfonamides, corticosteroids, tetracyclines, trimethoprim, chloramphenicol, paraaminobenzoic and paraaminohippuric acids, probenecid.
  • No interactions
    • ⓘ Celecoxib has no effect on the pharmacokinetics of methotrexate.
    • ⓘ Despite the possibility of interaction, studies of methotrexate in patients with rheumatoid arthritis, usually with simultaneous administration of NSAIDs in fixed doses, have not revealed any obvious problems.
  • Unclear interactions
    • ⓘ Methotrexate.
    • ⓘ НПВС.
    • ⓘ Hepatotoxic drugs.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine