Compatibility «Sildenafil» and «Metoprolol succinate»
Between «Sildenafil» and «Metoprolol succinate» found 3 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Metoprolol succinate |
| ✘Sildenafil Analogs | |
| ✘Metoprolol succinate Analogs |
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Interactions Sildenafil with Metoprolol succinate
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Negative interactions
- The AUC of the active metabolite of sildenafil increases by 62% when taking loop and potassium-sparing diuretics and by 102% when taking non-specific beta-blockers (the clinical significance of these effects has not been determined).
- Inhibitors of the CYP3A4 isoenzyme and beta-blockers.
- It was found that in patients with PAH, the clearance of sildenafil decreases by approximately 30% when used concomitantly with weak or moderate inhibitors of the CYP3A4 isoenzyme and by 34% when used concomitantly with beta-blockers.
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No interactions
- CYP2C9 inhibitors (tolbutamide, warfarin), CYP2D6 (selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazides and thiazide-like diuretics, loop and potassium-sparing diuretics, ACE inhibitors, calcium antagonists, beta-blockers and cytochrome P450 inducers (rifampicin, barbiturates) have no effect on pharmacokinetics of sildenafil.
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Negative interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
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- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-12-19
Category - medicine