Compatibility «Ritonavir» and «Atorvastatin»
Between «Ritonavir» and «Atorvastatin» found 3 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Atorvastatin |
✘Ritonavir Analogs | |
✘Atorvastatin Analogs |
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Interactions Ritonavir with Atorvastatin
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Negative interactions
- It is possible to interact with simultaneous use of atorvastatin with CYP3A4 inhibitors such as grapefruit juice, some macrolide antibiotics (e.g. erythromycin, clarithromycin), immunosuppressants (cyclosporine), azole antifungal drugs (e.g. itraconazole, ketoconazole), vector inhibitors, HIV and hepatitis C protease inhibitors, letermovir or the antidepressant nefazodone.
- Simultaneous use of atorvastatin and a combination of tipranavir + ritonavir or atorvastatin and telaprevir should be avoided.
- The dose of the saquinavir + ritonavir combination shown in this table is not a clinically used dose.
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No interactions
- Atorvastatin at a dose of 10 mg once did not affect the pharmacokinetics of the combination tipranavir + ritonavir.
- The use of atorvastatin at a dose of 10 mg once a day for 4 days did not affect the pharmacokinetics of fosamprenavir at a dose of 700 mg 2 times a day and ritonavir at a dose of 100 mg 2 times a day for 14 days (the ratio of AUC and max'>Cmax atorvastatin: 0.99 and 0.94, respectively, compared with the use of atorvastatin alone).
- When used in combination with boceprevir, combinations of saquinavir + ritonavir, darunavir + ritonavir, fosamprenavir or a combination of fosamprenavir + ritonavir, the dose of atorvastatin should be limited to 20 mg / day.
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Unclear interactions
- Hypolipidemic agents of the class of HMG-CoA reductase inhibitors lovastatin, simvastatin, atorvastatin, rosuvastatin.
- With simultaneous use of atorvastatin at a dose of 20 mg 1 time per day and a combination of lopinavir + ritonavir (400 + 100 mg 2 times per day) and atorvastatin monotherapy, the ratio of AUC and max '>Cmax atorvastatin was 5.9 and 4.7, respectively.
- With simultaneous use of atorvastatin at a dose of 10 mg once and a combination of tipranavir + ritonavir (500 + 200 mg 2 times a day) and atorvastatin monotherapy, the ratio of AUC and max'>Cmax atorvastatin was 9.4 and 8.6, respectively.
- With simultaneous use of atorvastatin at a dose of 40 mg once a day and ritonavir at a dose of 400 mg 2 times a day for 15 days and saquinavir at a dose of 400 mg 2 times a day, the ratio of AUC and max'>Cmax atorvastatin was 3.9 and 4.3 accordingly, compared with the use of atorvastatin alone.
- With simultaneous use of atorvastatin at a dose of 10 mg 1 time per day for 4 days and darunavir at a dose of 300 mg 2 times a day and ritonavir at a dose of 100 mg 2 times a day for 9 days, the ratio of AUC and max '>Cmax atorvastatin It was 3.4 and 2.2, respectively, compared with the use of atorvastatin alone.
- With simultaneous use of atorvastatin at a dose of 10 mg 1 time per day for 4 days and fosamprenavir at a dose of 700 mg 2 times a day and ritonavir at a dose of 100 mg 2 times a day for 14 days, the ratio of AUC and max '>Cmax atorvastatin It was 2.5 and 2.8, respectively, compared with the use of atorvastatin alone.
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Negative interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
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- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-12-19
Category - medicine