Compatibility «Meloxicam» and «Warfarin»

• Interactions Meloxicam with Warfarin

  • Dangerous interactions
    • ⓘ When used simultaneously with anticoagulants (heparin, ticlopidine, warfarin), as well as with thrombolytic drugs (streptokinase, fibrinolysin), the risk of bleeding increases (blood clotting indicators should be periodically monitored).
    • ⓘ Warfarin and NSAIDs have a synergistic effect on gastrointestinal bleeding, therefore, when combined with these drugs, the risk of developing serious gastrointestinal bleeding is higher than when using each of these drugs separately.
    • ⓘ Anticoagulant activity should be monitored, especially in the first few days after starting or changing therapy with meloxicam tablets in patients receiving warfarin or similar drugs, since these patients are at increased risk of bleeding.
    • ⓘ Caution should be exercised when prescribing meloxicam tablets to patients receiving warfarin due to possible changes in INR and an increased risk of bleeding.
    • ⓘ The risk of bleeding increases with the simultaneous use of NSAIDs and warfarin.
    • ⓘ Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics¹ (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants¹, antidepressants¹, intravaginal and systemic antifungal drugs¹, antimalarial drugs, antitumor drugs¹, antiparasitic and antimicrobial drugs¹, platelet aggregation inhibitors, antiteroid drugs¹, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics¹, drugs that regulate the acidity of gastric juice and anti-ulcer drugs¹, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs¹, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)¹, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins¹.
  • Negative interactions
    • ⓘ Careful monitoring of patients receiving NSAIDs is recommended to ensure that no dose adjustment of anticoagulants is required.
  • No interactions
    • ⓘ In these patients, meloxicam had no effect on the pharmacokinetics and the average anticoagulant effect of warfarin, determined by PV.
  • Unclear interactions
    • ⓘ Warfarin.
    • ⓘ The effect of meloxicam on the anticoagulant effect of warfarin was studied in a group of healthy volunteers who received daily doses of warfarin, which provided INR from 1.2 to 1.8.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine