Compatibility «Pancreatin» and «Dienogest+Estradiol valerate»

• Interactions Pancreatin with Dienogest+Estradiol valerate

  • Negative interactions
    • ⓘ It is possible to interact with drugs that induce microsomal liver enzymes, as a result of which the clearance of sex hormones may increase, which, in turn, may lead to 'breakthrough' uterine bleeding and/ or a decrease in the contraceptive effect.
    • ⓘ Induction of microsomal liver enzymes can be observed after a few days of combined use of inducer drugs and Clair's drug and persist up to 4 weeks after its termination.
    • ⓘ Substances that increase the clearance of COCs (reducing the effectiveness by inducing enzymes): phenytoin, barbiturates, bosentan, primidone, carbamazepine, rifampicin and, possibly.
  • Positive interactions
    • ⓘ Women who receive long-term treatment with drugs that induce microsomal liver enzymes are recommended to consider another effective non-hormonal method of contraception.
  • Unclear interactions
    • ⓘ Women who receive treatment with drugs that induce microsomal liver enzymes should temporarily use a barrier method of contraception or choose another non-hormonal method of contraception in addition to taking the drug Claira.
    • ⓘ Substances that reduce the clearance of COCs (enzyme inhibitors).
    • ⓘ However, based on the data of in vitro studies, inhibition of CYP enzymes when using Claira at a therapeutic dose is unlikely.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine