Compatibility «Clarithromycin» and «Velpatasvir+Sofosbuvir»

• Interactions Clarithromycin with Velpatasvir+Sofosbuvir

  • Dangerous interactions
    • ⓘ In this regard, the simultaneous use of lansoprazole with antiviral drugs such as atazanavir and nelfinavir is contraindicated.
  • Negative interactions
    • ⓘ Lansoprazole has been shown to interact with some antiviral drugs.
    • ⓘ With the simultaneous use of lansoprazole and some antiviral drugs, such as atazanavir and nelfinavir, against the background of therapy with lansoprazole, there is a decrease in their concentration in blood serum.
    • ⓘ In an in vitro study, a slow metabolic turnover of velpatasvir was observed through the isoenzymes CYP2B6, CYP2C8 and CYP3A4.
    • ⓘ Drugs that are strong inducers of P-gp or strong inducers of CYP2B6, CYP2C8 or CYP3A4 isoenzymes (for example, carbamazepine, phenobarbital and phenytoin, rifampicin, rifabutin, St. John's wort (Hypericum perforatum), can reduce the concentration of velpatasvir or sofosbuvir in blood plasma, which leads to a decrease in the therapeutic effect of velpatasvir / sofosbuvir.
  • Positive interactions
    • ⓘ An increase in the pH value during therapy with lansoprazole may affect the absorption of antiviral drugs.
  • Unclear interactions
    • ⓘ Medications that inhibit OATP, CYP2B6, CYP2C8 or CYP3A4 may increase the concentration of velpatasvir in blood plasma.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine