Compatibility «Omeprazole» and «Atazanavir»

• Interactions Omeprazole with Atazanavir

  • Dangerous interactions
    • ⓘ In patients with HIV, in the absence of a possible or detected decrease in sensitivity to atazanavir, it is recommended to use a combination of atazanavir 400 mg /ritonavir 100 mg with omeprazole at a maximum dose of 20 mg once a day (or another drug from the proton pump inhibitor group at an equivalent dose).
  • Negative interactions
    • ⓘ Simultaneous use of atazanavir and nelfinavir with proton pump inhibitors is not recommended, etc.; a significant decrease in the concentration of atazanavir in blood plasma is expected, which may lead to loss of therapeutic effect and the development of drug resistance.
    • ⓘ An increase in the pH of the stomach during treatment with omeprazole may alter the absorption of antiretroviral drugs.
    • ⓘ Decrease in the concentration of atazanavir and nelfinavir.
    • ⓘ For some antiretroviral drugs, such as atazanavir and nelfinavir, a decrease in serum levels has been reported when used concomitantly with omeprazole.
    • ⓘ After repeated doses of atazanavir (400 mg, daily) and omeprazole (40 mg, daily, 2 hours before atazanavir), AUC was reduced by 94%, C _max - by 96%, and C_min - by 95%.
    • ⓘ For other antiretroviral drugs, such as saquinavir, an increase in its serum level was reported with an increase in AUC by 82%, max'>C_max by 75% and C_min by 106% after repeated administration of the combination saquinavir + ritonavir (1000 + 100 mg) 2 times a day for 15 days with simultaneous administration of omeprazole at 40 mg / day for 11-15 days.
    • ⓘ As with other drugs that reduce the acidity of gastric juice, the absorption of drugs such as ketoconazole, atazanavir, iron salts, erlotinib and mycophenolate mofetil may decrease, while the absorption of drugs such as digoxin may increase during treatment with omeprazole.
    • ⓘ During treatment with atazanavir, proton pump inhibitors are prescribed only if their use is extremely indicated.
    • ⓘ With the combined use of atazanavir 400 mg or a combination of atazanavir 300 mg / ritonavir 100 mg with omeprazole 40 mg (all drugs once a day), there is a significant decrease in the concentration of atazanavir in blood plasma, which can lead to a decrease in the therapeutic activity of the drug and to the development of resistance.
    • ⓘ It is not recommended to use omeprazole at a dose of more than 20 mg per day (or another drug from the proton pump inhibitor group at an equivalent dose).
  • No interactions
    • ⓘ Combination with antiretroviral therapy.
  • Unclear interactions
    • ⓘ Omeprazole has been reported to interact with some antiretroviral drugs.
    • ⓘ Therefore, the simultaneous use of atazanavir and nelfinavir with omeprazole is not recommended.
    • ⓘ There are also some antiretroviral drugs, the level of which in the blood serum has not changed with the simultaneous use of omeprazole.
    • ⓘ Proton pump inhibitors.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine