Compatibility «Amlodipine» and «Sildenafil»

• Interactions Amlodipine with Sildenafil

  • Negative interactions
    • ⓘ With the simultaneous use of sildenafil with amlodipine, monitoring is necessary to detect signs of arterial hypotension.
    • ⓘ There were no signs of interaction with amlodipine (5 and 10 mg): an average additional decrease in blood pressure in the supine position (sAD by 8 mmHg.
    • ⓘ When studying the interaction of sildenafil (100 mg) with amlodipine in patients with arterial hypertension, an additional decrease in sAD and dAD in the supine position by 8 and 7 mmHg was noted.
  • No interactions
    • ⓘ The combined use of cimetidine, antacids containing magnesium and aluminum hydroxide, sildenafil and grapefruit juice does not affect the exposure of amlodipine.
    • ⓘ A single dose of 100 mg of sildenafil in patients with essential hypertension has no effect on the pharmacokinetics of amlodipine.
    • ⓘ CYP2C9 inhibitors (tolbutamide, warfarin), CYP2D6 (selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazides and thiazide-like diuretics, loop and potassium-sparing diuretics, ACE inhibitors, calcium antagonists, beta-blockers and cytochrome P450 inducers (rifampicin, barbiturates) have no effect on pharmacokinetics of sildenafil.
  • Positive interactions
    • ⓘ When amlodipine and sildenafil were used in combination, each independently had its own effect of lowering blood pressure.
  • Unclear interactions
    • ⓘ Sildenafil.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine