Compatibility «Ramipril» and «Spironolactone»

• Interactions Ramipril with Spironolactone

  • Dangerous interactions
    • ⓘ Simultaneous administration of Spironolactone Medisorb with other potassium-sparing diuretics, ACE inhibitors, ARA II, aldosterone blockers, potassium preparations, as well as adherence to a potassium-rich diet, or the use of potassium-containing salt substitutes, can lead to the development of severe hyperkalemia.
    • ⓘ Since ACE inhibitors reduce the production of aldosterone, drugs of this group should not be used in conjunction with spironolactone on a regular basis, especially in patients with established renal dysfunction.
  • Negative interactions
    • ⓘ The effects are enhanced by antihypertensive agents, including beta-blockers, in pm with significant systemic absorption from ophthalmic forms, diuretics, opioid analgesics, drugs for anesthesia, alcohol.
    • ⓘ Reduces secondary hyperaldosteronism and hypokalemia caused by diuretics.
    • ⓘ Potassium-sparing diuretics, cyclosporine, potassium-containing drugs and additives, salt substitutes, low-salt milk increase the risk of hyperkalemia.
    • ⓘ With potassium salts, potassium-sparing diuretics (for example, amiloride, spironolactone, triamterene, eplerenone (a derivative of spironolactone)), other drugs capable of increasing serum potassium (including ARA II, tacrolimus, cyclosporine; trimethoprim, sulfamethoxazole, which are part of co-trimoxazole (a combined antibacterial agent containing sulfamethoxazole and trimethoprim)).
    • ⓘ With antihypertensive drugs (for example, diuretics) and other drugs that reduce blood pressure (nitrates, tricyclic antidepressants, general and local anesthesia, baclofen, alfuzosin, doxazosin, prazosin, tamsulosin, terazosin).
    • ⓘ Potentiation of the antihypertensive effect; in relation to combination with diuretics, see also the sections 'Method of administration and doses', 'Side effect', 'Special instructions', when combined with diuretics, the sodium content in blood serum should be regularly monitored.
    • ⓘ ACE inhibitors (C09A) + potassium-sparing diuretics => Severe hypotension, risk of renal failure, hyperkalemia.
    • ⓘ Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia.
    • ⓘ Antihypertensive drugs: spironolactone potentiates the effect of antihypertensive drugs, the dose of which, when taken simultaneously with spironolactone, may need to be reduced and adjusted further if necessary.
  • Unclear interactions
    • ⓘ ACE inhibitors.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine