Compatibility «Fluoxetine» and «Amitriptyline»

• Interactions Fluoxetine with Amitriptyline

  • Dangerous interactions
    • ⓘ Microsomal oxidation inhibitors (cimetidine) prolong T1/2, increase the risk of toxic effects of amitriptyline (a dose reduction of 20-30% may be required), inducers of microsomal liver enzymes (barbiturates, carbamazepine, phenytoin, nicotine and oral contraceptives) they reduce plasma concentrations and reduce the effectiveness of amitriptyline.
  • Negative interactions
    • ⓘ The simultaneous use of fluoxetine and other drugs metabolized by CYP2D6, including some antidepressants (e.g. tricyclic antidepressants), neuroleptics (e.g. phenothiazines and most atypical neuroleptics) and antiarrhythmic drugs (e.g. propafenone, flecainide), should be approached with caution.
    • ⓘ Drugs with a narrow therapeutic index (for example, flecainide, propafenone, vinblastine and tricyclic antidepressants) are of the greatest concern.
    • ⓘ Thus, it may be necessary to reduce the dose of tricyclic antidepressants and temporarily monitor the concentration of tricyclic antidepressants in plasma with simultaneous use of fluoxetine or recent discontinuation of administration (see 'Precautions').
    • ⓘ Fluoxetine and Amitriptyline belong to the same pharmaceutical group: Antidepressants.
    • ⓘ Fluoxetine and fluvoxamine increase the concentration of amitriptyline in plasma (it may be necessary to reduce the dose of amitriptyline by 50%).
  • Unclear interactions
    • ⓘ Thus, this study suggests that drugs that inhibit CYP2D6, such as some SSRIs, including fluoxetine, cause an increase in plasma thioridazine levels.
    • ⓘ Tricyclic antidepressants.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

▶

Look at ▶Youtube

Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
  • Point the doctor to the found interaction - you may need to adjust the therapy.
  • Do you need an API for interactions/drug analogues for your project? Write to us.
• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,023,408 possible combinations of drugs and their components were found 412,559 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2025-11-20

Category - medicine