Compatibility «Fluoxetine» and «Thioridazine»

• Interactions Fluoxetine with Thioridazine

  • Dangerous interactions
    • ⓘ Due to the risk of serious ventricular arrhythmias and sudden death, potentially associated with elevated plasma levels of thioridazine, thioridazine should not be used with fluoxetine or for at least 5 weeks after discontinuation of fluoxetine (see 'Contraindications').
    • ⓘ Fluoxetine should not be used in combination with thioridazine or pimozide.
  • Negative interactions
    • ⓘ Thioridazine should not be used with fluoxetine or for at least 5 weeks after discontinuation of fluoxetine due to the risk of prolongation of the QT interval (see 'Contraindications' and 'Precautions').
    • ⓘ In a study in 19 healthy male volunteers, which included 6 slow and 13 fast metabolizers of debrisochine, a single oral dose of 25 mg of thioridazine caused a 2.4 times higher max'>C_max and a 4.5 times higher AUC for thioridazine in slow metabolizers by compared with fast metabolizers.
    • ⓘ The use of thioridazine causes a dose-dependent prolongation of the QT interval, which is associated with serious ventricular arrhythmias, such as torsade de pointes type arrhythmias, and sudden death.
    • ⓘ This risk is expected to increase with inhibition of thioridazine metabolism induced by fluoxetine.
    • ⓘ The simultaneous use of fluoxetine and other drugs metabolized by CYP2D6, including some antidepressants (e.g. tricyclic antidepressants), neuroleptics (e.g. phenothiazines and most atypical neuroleptics) and antiarrhythmic drugs (e.g. propafenone, flecainide), should be approached with caution.
  • Unclear interactions
    • ⓘ Thioridazine.
    • ⓘ Thus, this study suggests that drugs that inhibit CYP2D6, such as some SSRIs, including fluoxetine, cause an increase in plasma thioridazine levels.
    • ⓘ Neuroleptics.
    • ⓘ Some clinical data suggest possible FDV and/or FCV of SSRIs and neuroleptics.
    • ⓘ These include specific neuroleptics (for example, ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol), specific antibiotics (for example, erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), class IA antiarrhythmic agents (for example, quinidine, procainamide), class III antiarrhythmic agents (for example, amiodarone, sotalol) and others (for example, pentamidine, levomethadyl acetate, methadone, halophantrine, mefloquine, dolacetron mesylate, probucol or tacrolimus).

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 169,994,378 possible combinations of drugs and their components were found 412,530 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2024-12-19

Category - medicine