Compatibility «Warfarin» and «Rivaroxaban»
Between «Warfarin» and «Rivaroxaban» found 5 dangerous and 7 negative interactions, joint admission is not recommended without consulting a doctor.
Interaction tableCompare |
Rivaroxaban |
✘Warfarin Analogs | |
✘Rivaroxaban Analogs |
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Interactions Warfarin with Rivaroxaban
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Dangerous interactions
Exogenous factors: potentially possible interaction of warfarin and drugs of the following classes and groups: 5-lipoxygenase inhibitors, adrenostimulants, drugs of central action to reduce alcohol abuse, analgesics, inhaled anesthetics, antiandrogens, antiarrhythmic drugs, antibiotics1 (oral aminoglycosides, parenteral cephalosporins, macrolides, IV high-dose penicillins, macrolides, tetracyclines), quinolone antibacterial drugs, long-acting sulfonamides, anticoagulants, anticonvulsants1, antidepressants1, intravaginal and systemic antifungal drugs1, antimalarial drugs, antitumor drugs1, antiparasitic and antimicrobial drugs1, platelet aggregation inhibitors, antiteroid drugs1, beta-blockers, cholelitolytic drugs, antidiabetic drugs, oral diuretics1, drugs that regulate the acidity of gastric juice and anti-ulcer drugs1, prokinetics, drugs for the treatment of gout, hemorheological drugs, drugs for the treatment of ulcerative colitis, hepatotoxic drugs, hyperglycemic drugs, emergency medications for hypertension, hypnotic drugs1, leukotriene receptor antagonists, lipid-lowering drugs (fibrates, HMG-CoA reductase inhibitors, bile acid sequestrants)1, MAO inhibitors, long-acting narcotic drugs, drugs of natural origin, NSAIDs (non-selective COX-2 inhibitors), psychostimulants, pyrazolones, salicylates, SSRIs, adrenocorticosteroids, anabolic steroids (derivatives of 17-alkyltestosterone), thrombolytics, thyroid agents, anti-tuberculosis drugs, uricosuric drugs, vaccines, vitamins1. The simultaneous use of enoxaparin sodium, warfarin, acetylsalicylic acid, clopidogrel and the constant use of NSAIDs may increase the risk of bleeding. Concomitant use of rivaroxaban with other anticoagulants should be avoided due to the increased risk of bleeding, unless the benefit exceeds the risk. Due to the increased risk of bleeding, caution should be exercised when combined with any other anticoagulants (see 'Contraindications', WITH CAUTION and 'Special instructions'). As with other anticoagulants, caution should be exercised when using Xarelto with SSRIs and SSRIs, since the use of these drugs increases the risk of bleeding. -
Negative interactions
Numerous factors, individually or in combination, including travel, changes in diet, environment, physical condition or taking drugs, or the use of drugs of natural origin, can affect the patient's response to anticoagulants, including warfarin. Careful monitoring of patients receiving NSAIDs is recommended to ensure that no dose adjustment of anticoagulants is required. This makes it even more difficult to further assess the potential interaction and effect on the action of anticoagulants. Other drugs of natural origin with anticoagulant properties. Warfarin and Rivaroxaban belong to the same pharmaceutical group: Anticoagulants. In another study, single doses of warfarin (15 mg) and rivaroxaban (5 mg) resulted in an additive effect on the inhibition of factor Xa and PV. Starting from the 4th day after discontinuation of warfarin, all laboratory parameters (in pm, APTT, inhibition of factor Xa and EPT activity) reflect only the effect of the drug Xarelto (see 'Method of administration and doses'). -
No interactions
Neither enoxaparin sodium nor warfarin affected the pharmacokinetics of rivaroxaban. If it is necessary to study the pharmacodynamic effects of Xarelto during the transition period, the necessary tests that are not affected by warfarin can be used to determine the activity of the anti-factor Xa, prothrombinase-induced clotting time and NepTest. If it is necessary to investigate the pharmacodynamic effects of warfarin during the transition period, you can use the MHO value at Ctrouble rivaroxaban (24 hours after taking the first dose of rivaroxaban), etc.; at this point in time, rivaroxaban has virtually no effect on this indicator. -
Positive interactions
The transition of patients from warfarin (MHO = 2 to 3) to Xarelto (20 mg) or from Xarelto (20 mg) to warfarin (MHO = 2 to 3) increased PV/INR (Neoplastin) more than with a simple summation of effects (individual MHO values can reach 12), while the effect on APTT, the suppression of factor Xa activity and the effect on the endogenous potential of thrombin (EPT) was additive. Direct-acting anticoagulants (heparin) + Anticoagulants of indirect action => Mutual enhancement of action, hemorrhagic syndrome is possible. -
Unclear interactions
Anticoagulants. Anticoagulants and NSAIDs/acetylsalicylic acid. No PCBs have been reported between warfarin and the drug Xarelto.
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Dangerous interactions
Decoding the colors of interactions and contraindications
Dangerous | — | a pronounced negative interaction or contraindication. |
Negative | — | negative interaction or side effect that may reduce effectiveness. |
Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication of the drug. |
No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 169,974,420 possible combinations of drugs and their components were found 412,510 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2024-05-02
Category - medicine